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A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-Phase Phosphopeptide Fragmentation Mechanism

[Image: see text] Protein histidine phosphorylation is increasingly recognized as a critical posttranslational modification (PTM) in central metabolism and cell signaling. Still, the detection of phosphohistidine (pHis) in the proteome has remained difficult due to the scarcity of tools to enrich an...

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Autori principali: Oslund, Rob C., Kee, Jung-Min, Couvillon, Anthony D., Bhatia, Vivek N., Perlman, David H., Muir, Tom W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183637/
https://ncbi.nlm.nih.gov/pubmed/25156620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507614f
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