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How Is Acetylcholinesterase Phosphonylated by Soman? An Ab Initio QM/MM Molecular Dynamics Study

[Image: see text] Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ACh) and terminates synaptic signals by reducing the effective concentration of ACh in the synaptic clefts. Organophosphate compounds irreversibly inhibit AChEs, leading t...

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書誌詳細
主要な著者: Sirin, Gulseher Sarah, Zhang, Yingkai
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2014
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183371/
https://ncbi.nlm.nih.gov/pubmed/24786171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp502712d
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