Induction B-cell depletion significantly prolongs survival of GTKO.hCD46Tg pig heart xenografts up to 8 months

Xenotransplantation of genetically modified pig organs offers great potential to address the shortage of human organs for allotransplantation. Persistence of hyperacute rejection in Gal KO pigs due to elicited non Gal antibody response required further genetic modifications of donor pigs and better...

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Autors principals: Mohiuddin, MM, Corcoran, PC, Singh, AK, Azimzadeh, A, Hoyt, RF, Thomas, ML, Eckhaus, MA, Seavey, C, Ayares, D, Pierson, RN, Horvath, KA
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182960/
https://ncbi.nlm.nih.gov/pubmed/22070772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2011.03846.x
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