Regulatory T Cells Enhance Mesenchymal Stem Cell Survival and Proliferation following Autologous Co-Transplantation in Ischemic Myocardium

OBJECTIVES: This study sought to investigate whether Treg cells provide a protective and supportive role when co-transplanted with MSCs. METHODS: In a porcine model of chronic ischemia, autologous MSCs were isolated and expanded ex vivo for 4 wks. Autologous Treg cells were freshly isolated from 100...

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Hauptverfasser: Zhou, Yifu, Singh, Avneesh K., Hoyt, Robert F., Wang, Suna, Yu, Zuxi, Hunt, Timothy, Kindzelski, Bogdan, Corcoran, Philip C., Mohiuddin, Muhammad M., Horvath, Keith A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182951/
https://ncbi.nlm.nih.gov/pubmed/25052825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2014.06.029
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