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PARC/CUL9 Mediates the Degradation of Mitochondrial-released Cytochrome c and Promotes Survival in Neurons and Cancer Cells

The ability to withstand mitochondrial damage is especially critical for cells such as neurons that survive long-term. We report that cytochrome c (cyt c), a key trigger of apoptosis that is released upon mitochondrial permeabilization, is targeted for proteasome-mediated degradation in postmitotic...

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Dettagli Bibliografici
Autori principali: Gama, Vivian, Swahari, Vijay, Schafer, Johanna, Kole, Adam J., Evans, Allyson, Huang, Yolanda, Cliffe, Anna, Golitz, Brian, Sciaky, Noah, Pei, Xin-Hai, Xiong, Yue, Deshmukh, Mohanish
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182917/
https://ncbi.nlm.nih.gov/pubmed/25028717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005309
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