Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain

BACKGROUND: Gabapentin (GBP) is known to suppress neuropathic hypersensitivity of primary afferents and the spinal cord dorsal horn. However, its supra-spinal action sites are unclear. We identify the brain regions where GBP changes the brain glucose metabolic rate at the effective dose that allevia...

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Détails bibliographiques
Auteurs principaux: Lin, Hsiao-Chun, Huang, Yu-Hsin, Chao, Tzu-Hao Harry, Lin, Wen-Ying, Sun, Wei-Zen, Yen, Chen-Tung
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182821/
https://ncbi.nlm.nih.gov/pubmed/25253440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-63
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