MiR-410 Is Overexpressed in Liver and Colorectal Tumors and Enhances Tumor Cell Growth by Silencing FHL1 via a Direct/Indirect Mechanism

FHL1 is an important tumor-suppressor that is downregulated in multiple tumors by unknown mechanisms. We demonstrated that miR-410 specifically targets the 3′UTR of FHL1. Furthermore, using DNA bisulfite modification and sequencing experiments, we demonstrated that the FHL1 promoter is hypermethylat...

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Autors principals: Wang, Yu, Fu, Jie, Jiang, Mengmeng, Zhang, Xiaoai, Cheng, Long, Xu, Xiaojie, Fan, Zhongyi, Zhang, Jing, Ye, Qinong, Song, Haifeng
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182719/
https://ncbi.nlm.nih.gov/pubmed/25272045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108708
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