N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway

BACKGROUND: Hepatic ischemia–reperfusion injury (HIRI) remains a pivotal clinical problem after hemorrhagic shock, transplantation, and some types of toxic hepatic injury. Apoptosis and autophagy play important roles in cell death during HIRI. It is also known that N-acetylcysteine (NAC) has signifi...

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Hlavní autoři: Wang, Chengfen, Chen, Kan, Xia, Yujing, Dai, Weiqi, Wang, Fan, Shen, Miao, Cheng, Ping, Wang, Junshan, Lu, Jie, Zhang, Yan, Yang, Jing, Zhu, Rong, Zhang, Huawei, Li, Jingjing, Zheng, Yuanyuan, Zhou, Yingqun, Guo, Chuanyong
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4181678/
https://ncbi.nlm.nih.gov/pubmed/25264893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108855
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