Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment

Tumor-associated macrophages play an important role in tumor growth and progression. These macrophages are heterogeneous with diverse functions, eg, M1 macrophages inhibit tumor growth, whereas M2 macrophages promote tumor growth. In this study, we found that IFNγ and/or celecoxib (cyclooxygenase-2...

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Bibliographic Details
Main Authors: Ren, Fuqiang, Fan, Mingyu, Mei, Jiandong, Wu, Yongqiang, Liu, Chengwu, Pu, Qiang, You, Zongbing, Liu, Lunxu
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2014
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4181549/
https://ncbi.nlm.nih.gov/pubmed/25284985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S66302
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