Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain

O-GlcNAcylation is a modification that alters the function of numerous proteins. We hypothesized that augmented O-GlcNAcylation levels enhance myosin light chain kinase (MLCK) and reduce myosin light chain phosphatase (MLCP) activity, leading to increased vascular contractile responsiveness. The vas...

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Autors principals: Lima, V.V., Lobato, N.S., Filgueira, F.P., Webb, R.C., Tostes, R.C., Giachini, F.R.
Format: Artigo
Idioma:Inglês
Publicat: Associação Brasileira de Divulgação Científica 2014
Matèries:
Biomedical Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4181217/
https://ncbi.nlm.nih.gov/pubmed/25140811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1414-431X20144001
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