Deletions of chromosomal regulatory boundaries are associated with congenital disease

BACKGROUND: Recent data from genome-wide chromosome conformation capture analysis indicate that the human genome is divided into conserved megabase-sized self-interacting regions called topological domains. These topological domains form the regulatory backbone of the genome and are separated by reg...

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Hlavní autoři: Ibn-Salem, Jonas, Köhler, Sebastian, Love, Michael I, Chung, Ho-Ryun, Huang, Ni, Hurles, Matthew E, Haendel, Melissa, Washington, Nicole L, Smedley, Damian, Mungall, Christopher J, Lewis, Suzanna E, Ott, Claus-Eric, Bauer, Sebastian, Schofield, Paul N, Mundlos, Stefan, Spielmann, Malte, Robinson, Peter N
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180961/
https://ncbi.nlm.nih.gov/pubmed/25315429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0423-1
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