Magnetic Resonance Microscopy for Assessment of Morphological Changes in Hydrating Hydroxypropylmethylcellulose Matrix Tablets In Situ–Is it Possible to Detect Phenomena Related to Drug Dissolution Within the Hydrated Matrices?

PURPOSE: So far, the hydrated part of the HPMC matrix has commonly been denoted as a “gel” or “pseudogel” layer. No MRI-based results have been published regarding observation of internal phenomena related to drug dissolution inside swelling polymeric matrices during hydration. The purpose of the st...

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Main Authors: Kulinowski, Piotr, Młynarczyk, Anna, Jasiński, Krzysztof, Talik, Przemysław, Gruwel, Marco L. H., Tomanek, Bogusław, Węglarz, Władysław P., Dorożyński, Przemysław
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180912/
https://ncbi.nlm.nih.gov/pubmed/24633415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1334-2
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