Pretransplant Mobilization with Granulocyte Colony-Stimulating Factor Improves B-Cell Reconstitution by Lentiviral Vector Gene Therapy in SCID-X1 Mice

Hematopoietic stem cell (HSC) gene therapy is a demonstrated effective treatment for X-linked severe combined immunodeficiency (SCID-X1), but B-cell reconstitution and function has been deficient in many of the gene therapy treated patients. Cytoreductive preconditioning is known to improve HSC engr...

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Hlavní autoři: Huston, Marshall W., Riegman, Adriaan R.A., Yadak, Rana, van Helsdingen, Yvette, de Boer, Helen, van Til, Niek P., Wagemaker, Gerard
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2014
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180299/
https://ncbi.nlm.nih.gov/pubmed/25222508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2014.101
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