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Profile of selumetinib and its potential in the treatment of melanoma
The mitogen-activated protein kinase (MAPK) pathway is a critical oncogenic driver signal in a number of malignancies. The discovery of activating mutations in the MAPK pathway has led to the development of MAPK pathway inhibitors. Selumetinib is a potent and selective inhibitor of MEK1 and MEK2, wh...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4179759/ https://ncbi.nlm.nih.gov/pubmed/25278770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S51596 |
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