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Sildenafil use and increased risk of incident melanoma in US men: a prospective cohort study
IMPORTANCE: The RAS/RAF/MEK/ERK signaling pathway plays a crucial role in melanoma cell proliferation and survival. Sildenafil (Viagra) is a phosphodiesterase (PDE) 5A inhibitor commonly used for erectile dysfunction. Recent studies have shown that BRAF activation down-regulates PDE5A levels, and lo...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4178948/ https://ncbi.nlm.nih.gov/pubmed/24710960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamainternmed.2014.594 |
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