Inducible Gene Expression in Tumors Colonized by Modified Oncolytic Vaccinia Virus Strains

Exogenous gene induction of therapeutic, diagnostic, and safety mechanisms could be a considerable improvement in oncolytic virotherapy. Here, we introduced a doxycycline-inducible promoter system (comprised of a tetracycline repressor, several promoter constructs, and a tet operator sequence) into...

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Bibliographic Details
Main Authors: Stritzker, Jochen, Huppertz, Sascha, Zhang, Qian, Geissinger, Ulrike, Härtl, Barbara, Gentschev, Ivaylo, Szalay, Aladar A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178832/
https://ncbi.nlm.nih.gov/pubmed/25056902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00681-14
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