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Using Transcriptional Control To Increase Titers of Secreted Heterologous Proteins by the Type III Secretion System

The type III secretion system (T3SS) encoded at the Salmonella pathogenicity island 1 (SPI-1) locus secretes protein directly from the cytosol to the culture media in a concerted, one-step process, bypassing the periplasm. While this approach is attractive for heterologous protein production, produc...

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Detalhes bibliográficos
Main Authors: Metcalf, Kevin J., Finnerty, Casey, Azam, Anum, Valdivia, Elias, Tullman-Ercek, Danielle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178670/
https://ncbi.nlm.nih.gov/pubmed/25038096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01330-14
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