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A Protein Kinase A–Independent Pathway Controlling Aquaporin 2 Trafficking as a Possible Cause for the Syndrome of Inappropriate Antidiuresis Associated with Polycystic Kidney Disease 1 Haploinsufficiency

Renal water reabsorption is controlled by arginine vasopressin (AVP), which binds to V2 receptors, resulting in protein kinase A (PKA) activation, phosphorylation of aquaporin 2 (AQP2) at serine 256, and translocation of AQP2 to the plasma membrane. However, AVP also causes dephosphorylation of AQP2...

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Sonraí Bibleagrafaíochta
Main Authors: Tamma, Grazia, Lasorsa, Domenica, Trimpert, Christiane, Ranieri, Marianna, Di Mise, Annarita, Mola, Maria Grazia, Mastrofrancesco, Lisa, Devuyst, Olivier, Svelto, Maria, Deen, Peter M.T., Valenti, Giovanna
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178447/
https://ncbi.nlm.nih.gov/pubmed/24700872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013111234
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