Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10

The process of antibody ontogeny typically improves affinity, on-rate, and thermostability, narrows polyspecificity, and rigidifies the combining site to the conformer optimal for binding from the broader ensemble accessible to the precursor. However, many broadly-neutralizing anti-HIV antibodies in...

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Hauptverfasser: Finton, Kathryn A. K., Friend, Della, Jaffe, James, Gewe, Mesfin, Holmes, Margaret A., Larman, H. Benjamin, Stuart, Andrew, Larimore, Kevin, Greenberg, Philip D., Elledge, Stephen J., Stamatatos, Leonidas, Strong, Roland K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177983/
https://ncbi.nlm.nih.gov/pubmed/25254371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004403
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