Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor

BACKGROUND: EGFR-targeted therapy is an attractive option for head and neck squamous cell carcinoma patients. We have recently reported the use of EGFR inhibitors as an adjunct treatment to enhance HLA-DR expression in tumor cells to improve cancer immunotherapy. Nevertheless, we observed that EGFR...

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Bibliografske podrobnosti
Main Authors: Kumai, Takumi, Oikawa, Kensuke, Aoki, Naoko, Kimura, Shoji, Harabuchi, Yasuaki, Celis, Esteban, Kobayashi, Hiroya
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177691/
https://ncbi.nlm.nih.gov/pubmed/25240937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0265-3
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