A Bayesian Framework to Identify Methylcytosines from High-Throughput Bisulfite Sequencing Data

High-throughput bisulfite sequencing technologies have provided a comprehensive and well-fitted way to investigate DNA methylation at single-base resolution. However, there are substantial bioinformatic challenges to distinguish precisely methylcytosines from unconverted cytosines based on bisulfite...

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Detalhes bibliográficos
Main Authors: Xie, Qing, Liu, Qi, Mao, Fengbiao, Cai, Wanshi, Wu, Honghu, You, Mingcong, Wang, Zhen, Chen, Bingyu, Sun, Zhong Sheng, Wu, Jinyu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177668/
https://ncbi.nlm.nih.gov/pubmed/25255082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003853
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