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Structure-Based Simulations Reveal Concerted Dynamics of GPCR Activation

G protein-coupled receptors (GPCRs) are a vital class of proteins that transduce biological signals across the cell membrane. However, their allosteric activation mechanism is not fully understood; crystal structures of active and inactive receptors have been reported, but the functional pathway bet...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Leioatts, Nicholas, Suresh, Pooja, Romo, Tod D., Grossfield, Alan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177312/
https://ncbi.nlm.nih.gov/pubmed/24889093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24617
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