NOD2 Down-Regulates Colonic Inflammation by IRF4-Mediated Inhibition of K63-Linked Polyubiquitination of RICK and TRAF6

It is well established that polymorphisms of the nucleotide-binding oligomerization domain 2 (NOD2) gene, a major risk factor in Crohn's disease (CD), lead to loss of NOD2 function. However, a molecular explanation of how such loss of function leads to increased susceptibility to CD has remaine...

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Hauptverfasser: Watanabe, Tomohiro, Asano, Naoki, Meng, Guangxun, Yamashita, Kouhei, Arai, Yasuyuki, Sakurai, Toshiharu, Kudo, Masatoshi, Fuss, Ivan J, Kitani, Atsushi, Shimosegawa, Tooru, Chiba, Tsutomu, Strober, Warren
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177019/
https://ncbi.nlm.nih.gov/pubmed/24670424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.19
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