Clustered Conserved Cysteines in Hyaluronan Synthase Mediate Cooperative Activation by Mg(2+) Ions and Severe Inhibitory Effects of Divalent Cations

Hyaluronan synthase (HAS) uses UDP-GlcUA and UDP-GlcNAc to make hyaluronan (HA). Streptococcus equisimilis HAS (SeHAS) contains four conserved cysteines clustered near the membrane, and requires phospholipids and Mg(2+) for activity. Activity of membrane-bound or purified enzyme displayed a sigmoida...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Tlapak-Simmons, Valarie L., Medina, Andria P., Baggenstoss, Bruce A., Nguyen, Long, Baron, Christina A., Weigel, Paul H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176928/
https://ncbi.nlm.nih.gov/pubmed/25267933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2153-0637.S1-001
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky