Dasatinib Early Intervention After Cytogenetic or Hematologic Resistance to Imatinib in Patients With Chronic Myeloid Leukemia

BACKGROUND: Although many patients with chronic myeloid leukemia (CML) respond well to imatinib therapy, a significant proportion loses their initial response. Loss of response on imatinib is often because of BCR-ABL mutations. Dasatinib is a 325-fold more potent inhibitor of Bcr-Abl than imatinib a...

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Main Authors: Quintás-Cardama, Alfonso, Cortes, Jorge E., O'Brien, Susan, Ravandi, Farhad, Borthakur, Gautam, Liu, David, Bleickardt, Eric, Chen, Tai-Tsang, Kantarjian, Hagop M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176768/
https://ncbi.nlm.nih.gov/pubmed/19402171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.24325
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