Structural Basis of Binding and Rationale for the Potent Urease Inhibitory Activity of Biscoumarins

Urease belongs to a family of highly conserved urea-hydrolyzing enzymes. A common feature of these enzymes is the presence of two Lewis acid nickel ions and reactive cysteine residue in the active sites. In the current study we examined a series of biscoumarins 1–10 for their mechanisms of inhibitio...

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Hlavní autoři: Lodhi, Muhammad Arif, Shams, Sulaiman, Choudhary, Muhammad Iqbal, Lodhi, Atif, Ul-Haq, Zaheer, Jalil, Saima, Nawaz, Sarfraz Ahmad, Khan, Khalid Mohammed, Iqbal, Sajid, Rahman, Atta-ur
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176650/
https://ncbi.nlm.nih.gov/pubmed/25295281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/935039
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