Enhanced Fitness of Adult Spermatogonial Stem Cells Bearing a Paternal Age-Associated FGFR2 Mutation

Pathogenic de novo mutations increase with fathers’ age and could be amplified through competition between genetically distinct subpopulations of spermatogonial stem cells (SSCs). Here, we tested the fitness of SSCs bearing wild-type human FGFR2 or an Apert syndrome mutant, FGFR2 (S252W), to provide...

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Main Authors: Martin, Laura A., Assif, Nicholas, Gilbert, Moses, Wijewarnasuriya, Dinali, Seandel, Marco
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176532/
https://ncbi.nlm.nih.gov/pubmed/25254335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.06.007
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