Enhanced Fitness of Adult Spermatogonial Stem Cells Bearing a Paternal Age-Associated FGFR2 Mutation

Pathogenic de novo mutations increase with fathers’ age and could be amplified through competition between genetically distinct subpopulations of spermatogonial stem cells (SSCs). Here, we tested the fitness of SSCs bearing wild-type human FGFR2 or an Apert syndrome mutant, FGFR2 (S252W), to provide...

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Autori principali: Martin, Laura A., Assif, Nicholas, Gilbert, Moses, Wijewarnasuriya, Dinali, Seandel, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176532/
https://ncbi.nlm.nih.gov/pubmed/25254335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.06.007
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