Enhanced Fitness of Adult Spermatogonial Stem Cells Bearing a Paternal Age-Associated FGFR2 Mutation

Pathogenic de novo mutations increase with fathers’ age and could be amplified through competition between genetically distinct subpopulations of spermatogonial stem cells (SSCs). Here, we tested the fitness of SSCs bearing wild-type human FGFR2 or an Apert syndrome mutant, FGFR2 (S252W), to provide...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Martin, Laura A., Assif, Nicholas, Gilbert, Moses, Wijewarnasuriya, Dinali, Seandel, Marco
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2014
Gaiak:
Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176532/
https://ncbi.nlm.nih.gov/pubmed/25254335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.06.007
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