Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood–brain barrier model for drug permeability studies

BACKGROUND: Reliable human in vitro blood–brain barrier (BBB) models suitable for high-throughput screening are urgently needed in early drug discovery and development for assessing the ability of promising bioactive compounds to overcome the BBB. To establish an improved human in vitro BBB model, w...

詳細記述

保存先:
書誌詳細
主要な著者: Eigenmann, Daniela E, Xue, Gongda, Kim, Kwang S, Moses, Ashlee V, Hamburger, Matthias, Oufir, Mouhssin
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2013
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176484/
https://ncbi.nlm.nih.gov/pubmed/24262108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-8118-10-33
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