Selectively Targeting the DNA-binding Domain of the Androgen Receptor as a Prospective Therapy for Prostate Cancer

The androgen receptor (AR) is a transcription factor that has a pivotal role in the occurrence and progression of prostate cancer. The AR is activated by androgens that bind to its ligand-binding domain (LBD), causing the transcription factor to enter the nucleus and interact with genes via its cons...

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Détails bibliographiques
Auteurs principaux: Dalal, Kush, Roshan-Moniri, Mani, Sharma, Aishwariya, Li, Huifang, Ban, Fuqiang, Hessein, Mohamed, Hsing, Michael, Singh, Kriti, LeBlanc, Eric, Dehm, Scott, Tomlinson Guns, Emma S., Cherkasov, Artem, Rennie, Paul S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176249/
https://ncbi.nlm.nih.gov/pubmed/25086042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.553818
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