The Transcription Factor MEF/Elf4 Is Dually Modulated by p53-MDM2 Axis and MEF-MDM2 Autoregulatory Mechanism

Myeloid Elf-1-like factor (MEF) or Elf4 is an ETS transcription factor that activates innate immunity-associated genes such as lysozyme (LYZ), human β-defensin 2 (HβD2), and interleukin-8 (IL-8) in epithelial cells and is also known to influence cell cycle progression. MEF is transcriptionally activ...

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Bibliografiske detaljer
Main Authors: Suico, Mary Ann, Fukuda, Ryosuke, Miyakita, Rui, Koyama, Kosuke, Taura, Manabu, Shuto, Tsuyoshi, Kai, Hirofumi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176203/
https://ncbi.nlm.nih.gov/pubmed/25081543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580209
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