Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine

Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation from smooth (S) to rough (R) bacteria, the latter being inefficacious as...

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Bibliografiske detaljer
Main Authors: Mancilla, Marcos, Grilló, María-Jesús, de Miguel, María-Jesús, López-Goñi, Ignacio, San-Román, Beatriz, Zabalza-Baranguá, Ana, Moriyón, Ignacio
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176087/
https://ncbi.nlm.nih.gov/pubmed/24176078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1297-9716-44-105
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