Wld(S) prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca(2+) buffering

Wld(S) (slow Wallerian degeneration) is a remarkable protein that can suppress Wallerian degeneration of axons and synapses [1] but how it exerts this effect remains unclear [2]. Here, using Drosophila and mouse models, we identify mitochondria as a key site of action for Wld(S) neuroprotective func...

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Main Authors: Avery, Michelle A., Rooney, Timothy M., Pandya, Jignesh D., Wishart, Thomas M., Gillingwater, Thomas H., Geddes, James W., Sullivan, Patrick, Freeman, Marc R.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175988/
https://ncbi.nlm.nih.gov/pubmed/22425157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.02.043
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