Cytotoxic T-lymphocyte clones from different patients display limited T-cell-receptor variable-region gene usage in HLA-A2-restricted recognition of the melanoma antigen Melan-A/MART-1.

To determine whether T-cell-receptor (TCR) usage by T cells recognizing a defined human tumor antigen in the context of the same HLA molecule is conserved, we analyzed the TCR diversity of autologous HLA-A2-restricted cytotoxic T-lymphocyte (CTL) clones derived from five patients with metastatic mel...

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Detalhes bibliográficos
Main Authors: Sensi, M, Traversari, C, Radrizzani, M, Salvi, S, Maccalli, C, Mortarini, R, Rivoltini, L, Farina, C, Nicolini, G, Wölfel, T
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC41759/
https://ncbi.nlm.nih.gov/pubmed/7777568
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