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A complex iron-calcium cofactor catalyzing phosphotransfer chemistry

Alkaline phosphatases play a crucial role in phosphate acquisition by microorganisms. To expand our understanding of catalysis by this class of enzymes we have determined the structure of the widely-occurring microbial alkaline phosphatase PhoX. The enzyme contains a complex active site cofactor com...

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Detalhes bibliográficos
Main Authors: Yong, Shee Chien, Roversi, Pietro, Lillington, James, Rodriguez, Fernanda, Krehenbrink, Martin, Zeldin, Oliver B., Garman, Elspeth F., Lea, Susan M., Berks, Ben C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175392/
https://ncbi.nlm.nih.gov/pubmed/25190793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254237
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