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Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-independent Mechanism

Anti-tumor immune responses have been linked to the regulated release of ATP from apoptotic cancer cells to engage P2 purinergic receptor signaling cascades in nearby leukocytes. We used the Jurkat T cell acute lymphocytic leukemia model to characterize the role of pannexin-1 (Panx1) channels in the...

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Autori principali: Boyd-Tressler, Andrea, Penuela, Silvia, Laird, Dale W., Dubyak, George R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175357/
https://ncbi.nlm.nih.gov/pubmed/25112874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.590240
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