Deficiency of Cardiomyocyte-specific MicroRNA-378 Contributes to the Development of Cardiac Fibrosis Involving a Transforming Growth Factor β (TGFβ1)-dependent Paracrine Mechanism

Understanding the regulation of cardiac fibrosis is critical for controlling adverse cardiac remodeling during heart failure. Previously we identified miR-378 as a cardiomyocyte-abundant miRNA down-regulated in several experimental models of cardiac hypertrophy and in patients with heart failure. To...

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Main Authors: Nagalingam, Raghu S., Sundaresan, Nagalingam R., Noor, Mariam, Gupta, Mahesh P., Solaro, R. John, Gupta, Madhu
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175354/
https://ncbi.nlm.nih.gov/pubmed/25104350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580977
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