Chronic Ethanol Consumption Inhibits Glucokinase Transcriptional Activity by Atf3 and Triggers Metabolic Syndrome in Vivo

Chronic ethanol consumption induces pancreatic β-cell dysfunction through glucokinase (Gck) nitration and down-regulation, leading to impaired glucose tolerance and insulin resistance, but the underlying mechanism remains largely unknown. Here, we demonstrate that Gck gene expression and promoter ac...

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Detalhes bibliográficos
Main Authors: Kim, Ji Yeon, Hwang, Joo-Yeon, Lee, Dae Yeon, Song, Eun Hyun, Park, Keon Jae, Kim, Gyu Hee, Jeong, Eun Ae, Lee, Yoo Jeong, Go, Min Jin, Kim, Dae Jin, Lee, Seong Su, Kim, Bong-Jo, Song, Jihyun, Roh, Gu Seob, Gao, Bin, Kim, Won-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175344/
https://ncbi.nlm.nih.gov/pubmed/25074928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585653
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