Nuclear Heme Oxygenase-1 (HO-1) Modulates Subcellular Distribution and Activation of Nrf2, Impacting Metabolic and Anti-oxidant Defenses

With oxidative injury as well as in some solid tumors and myeloid leukemia cells, heme oxygenase-1 (HO-1), the anti-oxidant, anti-inflammatory, and anti-apoptotic microsomal stress protein, migrates to the nucleus in a truncated and enzymatically inactive form. However, the function of HO-1 in the n...

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Bibliografiske detaljer
Main Authors: Biswas, Chhanda, Shah, Nidhi, Muthu, Manasa, La, Ping, Fernando, Amal P., Sengupta, Shaon, Yang, Guang, Dennery, Phyllis A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175329/
https://ncbi.nlm.nih.gov/pubmed/25107906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.567685
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