Elimination of B-RAF in Oncogenic C-RAF-expressing Alveolar Epithelial Type II Cells Reduces MAPK Signal Intensity and Lung Tumor Growth

Tumors are often greatly dependent on signaling cascades promoting cell growth or survival and may become hypersensitive to inactivation of key components within these signaling pathways. Ras and RAF mutations found in human cancer confer constitutive activity to these signaling molecules thereby co...

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Dettagli Bibliografici
Autori principali: Zanucco, Emanuele, El-Nikhely, Nefertiti, Götz, Rudolf, Weidmann, Katharina, Pfeiffer, Verena, Savai, Rajkumar, Seeger, Werner, Ullrich, Axel, Rapp, Ulf R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175323/
https://ncbi.nlm.nih.gov/pubmed/25096573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558999
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