Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma

PURPOSE: To evaluate outer retinal structural abnormalities in patients with visual deficits following closed globe blunt ocular trauma (cgBOT). METHODS: Nine subjects with visual complaints following cgBOT were examined between 1 month post-trauma and 6 years post-trauma. Spectral domain optical co...

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Main Authors: Flatter, John A., Cooper, Robert F., Dubow, Michael J., Pinhas, Alexander, Singh, Ravi S., Kapur, Rashmi, Shah, Nishit, Walsh, Ryan D., Hong, Sang H., Weinberg, David V., Stepien, Kimberly E., Wirostko, William J., Robison, Scott, Dubra, Alfredo, Rosen, Richard B., Connor, Thomas B., Carroll, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175068/
https://ncbi.nlm.nih.gov/pubmed/24752010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/IAE.0000000000000169
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spelling pubmed-41750682015-10-01 Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma Flatter, John A. Cooper, Robert F. Dubow, Michael J. Pinhas, Alexander Singh, Ravi S. Kapur, Rashmi Shah, Nishit Walsh, Ryan D. Hong, Sang H. Weinberg, David V. Stepien, Kimberly E. Wirostko, William J. Robison, Scott Dubra, Alfredo Rosen, Richard B. Connor, Thomas B. Carroll, Joseph Retina Article PURPOSE: To evaluate outer retinal structural abnormalities in patients with visual deficits following closed globe blunt ocular trauma (cgBOT). METHODS: Nine subjects with visual complaints following cgBOT were examined between 1 month post-trauma and 6 years post-trauma. Spectral domain optical coherence tomography (SD-OCT) was used to assess outer retinal architecture, while adaptive optics scanning light ophthalmoscopy (AOSLO) was used to analyze photoreceptor mosaic integrity. RESULTS: Visual deficits ranged from central scotomas to decreased visual acuity. SD-OCT defects included focal foveal photoreceptor lesions, variable attenuation of the interdigitation zone, and mottling of the outer segment band, with one subject having normal outer retinal structure. AOSLO revealed disruption of the photoreceptor mosaic in all subjects, variably manifesting as foveal focal discontinuities, perifoveal hyporeflective cones, and paracentral regions of selective cone loss. CONCLUSIONS: We observe persistent outer retinal disruption in subjects with visual complaints following cgBOT, albeit to a variable degree. AOSLO imaging allows assessment of photoreceptor structure at a level of detail not resolvable using SD-OCT or other current clinical imaging tools. Multimodal imaging appears useful for revealing the cause of visual complaints in patients following cgBOT. Future studies are needed to better understand how photoreceptor structure changes longitudinally in response to various trauma. 2014-10 /pmc/articles/PMC4175068/ /pubmed/24752010 http://dx.doi.org/10.1097/IAE.0000000000000169 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Flatter, John A.
Cooper, Robert F.
Dubow, Michael J.
Pinhas, Alexander
Singh, Ravi S.
Kapur, Rashmi
Shah, Nishit
Walsh, Ryan D.
Hong, Sang H.
Weinberg, David V.
Stepien, Kimberly E.
Wirostko, William J.
Robison, Scott
Dubra, Alfredo
Rosen, Richard B.
Connor, Thomas B.
Carroll, Joseph
Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma
description PURPOSE: To evaluate outer retinal structural abnormalities in patients with visual deficits following closed globe blunt ocular trauma (cgBOT). METHODS: Nine subjects with visual complaints following cgBOT were examined between 1 month post-trauma and 6 years post-trauma. Spectral domain optical coherence tomography (SD-OCT) was used to assess outer retinal architecture, while adaptive optics scanning light ophthalmoscopy (AOSLO) was used to analyze photoreceptor mosaic integrity. RESULTS: Visual deficits ranged from central scotomas to decreased visual acuity. SD-OCT defects included focal foveal photoreceptor lesions, variable attenuation of the interdigitation zone, and mottling of the outer segment band, with one subject having normal outer retinal structure. AOSLO revealed disruption of the photoreceptor mosaic in all subjects, variably manifesting as foveal focal discontinuities, perifoveal hyporeflective cones, and paracentral regions of selective cone loss. CONCLUSIONS: We observe persistent outer retinal disruption in subjects with visual complaints following cgBOT, albeit to a variable degree. AOSLO imaging allows assessment of photoreceptor structure at a level of detail not resolvable using SD-OCT or other current clinical imaging tools. Multimodal imaging appears useful for revealing the cause of visual complaints in patients following cgBOT. Future studies are needed to better understand how photoreceptor structure changes longitudinally in response to various trauma.
author Flatter, John A.
Cooper, Robert F.
Dubow, Michael J.
Pinhas, Alexander
Singh, Ravi S.
Kapur, Rashmi
Shah, Nishit
Walsh, Ryan D.
Hong, Sang H.
Weinberg, David V.
Stepien, Kimberly E.
Wirostko, William J.
Robison, Scott
Dubra, Alfredo
Rosen, Richard B.
Connor, Thomas B.
Carroll, Joseph
author_facet Flatter, John A.
Cooper, Robert F.
Dubow, Michael J.
Pinhas, Alexander
Singh, Ravi S.
Kapur, Rashmi
Shah, Nishit
Walsh, Ryan D.
Hong, Sang H.
Weinberg, David V.
Stepien, Kimberly E.
Wirostko, William J.
Robison, Scott
Dubra, Alfredo
Rosen, Richard B.
Connor, Thomas B.
Carroll, Joseph
author_sort Flatter, John A.
title Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma
title_short Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma
title_full Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma
title_fullStr Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma
title_full_unstemmed Outer Retinal Structure Following Closed Globe Blunt Ocular Trauma
title_sort outer retinal structure following closed globe blunt ocular trauma
publishDate 2014
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4175068/
https://ncbi.nlm.nih.gov/pubmed/24752010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/IAE.0000000000000169
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