NR2B phosphorylation at Tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia

BACKGROUND AND PURPOSE: The NR2B subunit of the NMDA receptor (NMDAR) is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. While Y1472 phosphrylation is important for synaptic plasticity, it is unknown whether it is involved in NMDAR-medi...

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Main Authors: Knox, Renatta, Brennan-Minnella, Angela M., Lu, Fuxin, Yang, Diana, Nakazawa, Takanobu, Yamamoto, Tadashi, Swanson, Raymond A., Ferriero, Donna M., Jiang, Xiangning
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175024/
https://ncbi.nlm.nih.gov/pubmed/25158771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.114.006170
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