Soft Tissue Sarcoma Are Highly Sensitive to AKT Blockade: A Role for p53 Independent Up-regulation of GADD45α

The AKT signaling pathway is activated in soft tissue sarcoma (STS). However, AKT blockade has not yet been studied as a potential targeted therapeutic approach. Here we examined the in vitro and in vivo effects of AKT inhibition in STS cells. Western blot analysis was utilized to evaluate the expre...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhu, Quan-Sheng, Ren, Wenhong, Korchin, Borys, Lahat, Guy, Dicker, Adam, Lu, Yiling, Mills, Gordon, Pollock, Raphael E, Lev, Dina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174465/
https://ncbi.nlm.nih.gov/pubmed/18413758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6268
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