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TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high-grade intraepithelial neoplasia of the cervix

BACKGROUND: Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA gene variations in adenocarcinoma, squamous cell carcinoma as well as in int...

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Detalhes bibliográficos
Main Authors: Tornesello, Maria Lina, Annunziata, Clorinda, Buonaguro, Luigi, Losito, Simona, Greggi, Stefano, Buonaguro, Franco M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174264/
https://ncbi.nlm.nih.gov/pubmed/25220666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0255-5
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