Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals

Pattern recognition receptor (PRR) detection of pathogen-associated molecular patterns (PAMPs), such as viral RNA, drives innate immune responses against West Nile virus (WNV), an emerging neurotropic pathogen. Here we demonstrate that WNV PAMPs orchestrate endothelial responses to WNV via competing...

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Main Authors: Daniels, Brian P., Holman, David W., Cruz-Orengo, Lillian, Jujjavarapu, Harsha, Durrant, Douglas M., Klein, Robyn S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Microbiology 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173776/
https://ncbi.nlm.nih.gov/pubmed/25161189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01476-14
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