Systemic administration of 6-OHDA to rhesus monkeys upregulates HLA-DR expression in brain microvasculature

BACKGROUND: We recently developed a nonhuman primate model of cardiac dysautonomia by systemic dosing of the catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA). The aim of this study was to assess whether systemic 6-OHDA affects the central nervous system of nonhuman primates, in particular the...

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Autors principals: Joers, Valerie, Vermilyea, Scott, Dilley, Kristine, Emborg, Marina E
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2014
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173661/
https://ncbi.nlm.nih.gov/pubmed/25258551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S67285
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