Phase III trial (EORTC 10994/BIG 1-00) assessing the value of p53 using a functional assay to predict sensitivity to a taxane versus non taxane primary chemotherapy in breast cancer: final analysis

BACKGROUND: This study tested the hypothesis that docetaxel confers a greater advantage over anthracyclines in p53 mutant compared to p53 wild type breast cancers. METHODS: Patients with locally advanced, inflammatory or large operable breast cancers were randomised to receive neoadjuvant chemothera...

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Hauptverfasser: Bonnefoi, Hervé, Piccart, Martine, Bogaerts, Jan, Mauriac, Louis, Fumoleau, Pierre, Brain, Etienne, Petit, Thierry, Rouanet, Philippe, Jassem, Jacek, Blot, Emmanuel, Zaman, Khalil, Cufer, Tanja, Lortholary, Alain, Lidbrink, Elisabet, André, Sylvie, Litière, Saskia, Lago, Lissandra Dal, Becette, Véronique, Cameron, David A., Bergh, Jonas, Iggo, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172919/
https://ncbi.nlm.nih.gov/pubmed/21570352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(11)70094-8
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