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Two Protein N-Acetylgalactosaminyl Transferases Regulate Synaptic Plasticity by Activity-Dependent Regulation of Integrin Signaling

Using a Drosophila whole-genome transgenic RNAi screen for glycogenes regulating synapse function, we have identified two protein α-N-acetylgalactosaminyltransferases (pgant3 and pgant35A) that regulate synaptic O-linked glycosylation (GalNAcα1-O-S/T). Loss of either pgant alone elevates presynaptic...

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Hlavní autoři: Dani, Neil, Zhu, He, Broadie, Kendal
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172800/
https://ncbi.nlm.nih.gov/pubmed/25253852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1484-14.2014
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