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Library methods for structural biology of challenging proteins and their complexes
Genetic engineering of constructs to improve solubility or stability is a common approach, but it is often unclear how to obtain improvements. When the domain composition of a target is poorly understood, or if there are insufficient structure data to guide sited directed mutagenesis, long iterative...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4172339/ https://ncbi.nlm.nih.gov/pubmed/23602357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2013.03.004 |
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