Effects of benralizumab on airway eosinophils in asthma with sputum eosinophilia

BACKGROUND: Many subjects with asthma exhibit sputum eosinophilia associated with exacerbations. Benralizumab targets eosinophils by binding interleukin-5 receptor alpha, inducing apoptosis via antibody-dependent cell-mediated cytotoxicity. OBJECTIVES: To evaluate the safety of benralizumab in adult...

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Main Authors:	Laviolette, Michel, Gossage, David L, Gauvreau, Gail, Leigh, Richard, Olivenstein, Ron, Katial, Rohit, Busse, William W, Wenzel, Sally, Wu, Yanping, Datta, Vivekananda, Kolbeck, Roland, Molfino, Nestor A
Format:	Artigo
Sprog:	Inglês
Udgivet:	2013
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4172321/ https://ncbi.nlm.nih.gov/pubmed/23866823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.05.020
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Effects of benralizumab on airway eosinophils in asthma with sputum eosinophilia

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