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Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

The high-affinity interleukin 2 (IL-2) receptor (IL-2R) consists of three subunits: the IL-2R alpha, IL-2R beta c, and IL-2R gamma c chains. Two members of the Janus kinase family, Jak1 and Jak3, are associated with IL-2R beta c and IL-2R gamma c, respectively, and they are activated upon IL-2 stimu...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Fujii, H, Nakagawa, Y, Schindler, U, Kawahara, A, Mori, H, Gouilleux, F, Groner, B, Ihle, J N, Minami, Y, Miyazaki, T
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41719/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7777534/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.12.5482
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